The library
STUDIES ORGANIZED BY CATEGORIES
In the evidence corner these studies, instead of being organized by dates, are organized by other categories (drug class, surgery…).
The summaries in this section are presented in a much more reduced way.
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European Crohn's and Colitis Organization
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DIET
2024 metabolic and lifestyle factors associated with IBD and T2D
Metabolic and lifestyle factors accelerate disease onset and alter gut microbiome in inflammatory non-communicable diseases2024 Diet and Nutritional Therapies- AGA expert review
AGA Clinical Practice Update on Diet and Nutritional Therapies in Patients With Inflammatory Bowel Disease: Expert Review2023 ultraprocessed food-CD
Association of ultra-processed food intake with Crohn’s disease (Cross-sectional & prospective analysis-UK) -
Evidence Corner
Fecal stream diversion postop
2020 tacro/beclo
2017 topic tacro
2013 5ASA sup
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Type of drug
RISANKIZUMAB
UPADACITINIB
MIRIKIZUMAB
OZANIMOD
ETRASIMOD
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ULCERATIVE COLITIS
Montreal classification
Full Mayo Score (DAI-Disease activity index)
Partial Mayo score
Truelove-Witts severity index
Mayo endoscopic score
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Network meta-analysis
2021 5ASA oral, topical or combined in UC
2021 First & second line therapy in UC
2018 First & second line therapy in CD
2017 Mesalamine, Sulfasalazine, Corticosteroids & Budesonide in CD
2015 Immunosupressants & biologics in CD
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Crohn's Disease
2005 H Park et ak Th17 discovery, a unique T helper lineage that regulates tissue inflammation
2001 JP HUGOT association between NOD2 variants and CD risk
1997 First trial using infliximab in CD
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American Gastroenterological Association
2025 Living Clinical Practice Guideline on Pharmacological Management of Moderate-to-Severe Crohn’s disease
2024 Living Clinical Practice Guideline on Pharmacological Management of Moderate-to-Severe Ulcerative Colitis
2024 Management of IBD in patients with malignancy- Commentary
2024 Diet and Nutritional Therapies in IBD- Expert review
2023 Guideline on the Management of Pouchitis and Inflammatory Pouch Disorders
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ANTIBIOTICS
2023 Maternal antibiotic exposure & IBD in offspring
Maternal antibiotic exposure during pregnancy and risk of IBD in offspring: a population-based cohort study2024 Antibiotics & new onset IBD meta-analysis
Antibiotic exposure and risk of new-onset inflammatory bowel disease: a systematic review and dose-response meta-analysis2023 Antibiotics & new onset IBD meta-analysis
The association of antibiotic exposure with new-onset inflammatory bowel disease: A systematic review and meta-analysis2023 Antibiotic use & IBD Danish cohort
Antibiotic use as a risk factor for inflammatory bowel disease across the ages: a population-based cohort study2022 Perinatal antibiotic & IBD risk
Perinatal and Antibiotic Exposures and the Risk of Developing Childhood-Onset Inflammatory Bowel Disease: A Nested Case-Control Study Based on a Population-Based Birth Cohort -
Library
2010 Recombinant human interleukin 10 for induction of remission in CD
2010 Unfractionated or low‐molecular weight heparin for induction of remission in UC
2009 Open versus laparoscopic (assisted) IPAA in UC & FAP
2009 Interventions for prevention of post-operative recurrence of CD
2008 TNF‐alpha antibody for maintenance of remission in CD
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CROHN’S DISEASE
Montreal classification
Harvey-Bradshaw Index (HBI)
Crohn’s Disease Activity Index (CDAI)
Parks classification (perianal disease)
Rutgeerts classification
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Paediatric
Thalidomide kids UC
GOLI Kids
PAILOT
PRASCO
PRESENCE
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Cochrane Database of Systematic Reviews
2023 Vitamin D for the treatment of inflammatory bowel disease
2023 Vedolizumab for induction and maintenance of remission in Crohn’s disease
2023 Remote care through telehealth for people with IBD
2023 Patient education Interventions for the management of IBD
2022 Stem cell transplantation for induction of remission in medically refractory CD
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Ulcerative Colitis
2005 H Park et ak Th17 discovery, a unique T helper lineage that regulates tissue inflammation
2000 K GEBOES et al histological assessment of inflammation in ulcerative colitis
1987 KW Schroeder et al published the Full Mayo Score
1986 Tracey KJ et al Monoclonal antibody against TNF for septic shock due to bacteraemia
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GETECCU (Spanish Group for the study of Crohn's disease & ulcerative colitis)
2025 Position statement on the management of IBD in Primary Care
2025 Position statement on cardiovascular disease in patients with IBD
2025 position statement for the management of non-perianal fistulizing disease in CD
2024 Position statement on Therapeutic drug monitoring in IBD
2024 Position statement on the use of telemedicine in IBD
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Tobacco
2023 Maternal smoking, offspring smoking, genetic susceptibility & IBD risk
Impact of Maternal Smoking, Offspring Smoking, and Genetic Susceptibility on Crohn’s Disease and Ulcerative Colitis2022 smoking & IBD risk Taiwan
Effect of smoking on the development and outcomes of inflammatory bowel disease in Taiwan: a hospital-based cohort study2022 Causal role of smoking in IBD meta-analysis of Mendelian randomization studies
Appraising the causal role of smoking in multiple diseases: A systematic review and meta-analysis of Mendelian randomization studies2021 smoking & IBD in Denmark
Risk of ulcerative colitis and Crohn’s disease in smokers lacks causal evidence (Cases-Controls- Denmark)2021 Ethnic difference smoking IBD risk meta-analysis
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Guidelines
2006 Endoscopic diagnosis and treatment of IBD
2024 Pediatric to Adult Transition in IBD: Australia & New Zealand
2024 fibrostenosing small bowel CD
2022 Therapeutic drug monitoring of biologics in IBD
2022 Australian preconception, pregnancy and breast feeding in IBD
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Conception, pregnancy, postpartum & lactation
2024 Updates on IBD management from preconception to pregnancy & lactation
Updates on the management of inflammatory bowel disease from periconception to pregnancy and lactation2024 Thiopurine during pregnancy and intrahepatic cholestasis
Thiopurine Metabolite Shunting in Late Pregnancy Increases the Risk of Intrahepatic Cholestasis of Pregnancy in Women With Inflammatory Bowel Disease, and Can be Managed With Split Dosing2024 Safety of vedolizumab & ustekinumab vs antiTNF in IBD pregnant patients
Safety of vedolizumab and ustekinumab compared with anti-TNF in pregnant women with inflammatory bowel disease2024 pregnancy outcomes in the ozanimod program in uc, cd and multiple sclerosis
Pregnancy Outcomes in the Ozanimod Clinical Development Program in Patients With Ulcerative Colitis, Crohn’s Disease, and Relapsing Multiple Sclerosis2023 Tofactinib in plasma & breastmilk of women with UC
Tofacitinib concentrations in plasma and breastmilk of a lactating woman with ulcerative colitis -
PAEDIATRIC IBD SCORES
pediatric Crohn’s Disease Activity Index (PCDAI)
pediatric ulcerative colitis Activity Index (PUCAI)
Paris classification (Crohn’s disease)
Paris classification (ulcerative colitis)
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British Society of Gastroenterology
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APPENDICECTOMY
2004 Appendicectomy UC+PSC
2003 Appendicectomy and CD
2002 Australia case-control study IBD
Protective role of appendicectomy on onset and severity of ulcerative colitis and Crohn’s disease2001 Appendectomy & UC
2001 Appendicectomy and UC
Appendectomy protects against the development of ulcerative colitis and reduces its recurrence -
HISTOPATHOLOGY
GEBOES score
NANCY HISTOLOGICAL INDEX
Robarts histopathology index
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Classifications
pediatric Crohn’s Disease Activity Index (PCDAI)
pediatric ulcerative colitis Activity Index (PUCAI)
GEBOES score
NANCY HISTOLOGICAL INDEX
Robarts histopathology index
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Fertility, sexuality & paternal outcomes in men with IBD
2024 prevalence of sexual dysfunction in IBD- meta-analysis
Prevalence of Sexual Dysfunction in Inflammatory Bowel Disease: Systematic Review and Meta-analysis2024 male fertility & reproductive outcomes- meta-analysis
Prevalence of Sexual Dysfunction in Inflammatory Bowel Disease: Systematic Review and Meta-analysis2023 male fertility & reproductive outcomes- meta-analysis
Paternal Medications in Inflammatory Bowel Disease and Male Fertility and Reproductive Outcomes: A Systematic Review and Meta-analysis2022 Prevalence & risk factors of erectile dysfunction in IBD meta-analysis
The Prevalence and Associated Risk Factors of Erectile Dysfunction in Patients with Inflammatory Bowel Disease: A Systematic Review and Meta-analysis2021 Prevalence & risk factors for sexual dysfunction meta-analysis
Prevalence and risk factors of sexual dysfunction in patients with inflammatory bowel disease: systematic review and meta-analysis -
American College of Gastroenterology
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Microbiome
2023 Proteins & antimicrobial antibodies and CD
2023 Gut virome & UC
Gut virome-colonising *Orthohepadnavirus* genus is associated with ulcerative colitis pathogenesis and induces intestinal inflammation *in vivo*2023 Gut virome & IBD
2023 Gut microbiota signatures & IBD
2023 food-derived yeasts & CD
Selection of cross-reactive T cells by commensal and food-derived yeasts drives cytotoxic T~H~1 cell responses in Crohn’s disease -
Multifactorial
2025 severe obesity & IBD risk
Severe obesity, a susceptibility factor for developing inflammatory bowel disease: results of a population-based study2024 Sex-related differences and IBD course
Sex-Related Differences in the Phenotype and Course of Inflammatory Bowel Disease: SEXEII Study of ENEIDA2024 physical activity & IBD meta analysis
Physical Activity Is Associated With A Decreased Risk Of Developing Inflammatory Bowel Disease: A Systematic Review And Meta-Analysis2024 periodontitis & IBD
Causal Association Analysis of Periodontitis and Inflammatory Bowel Disease: A Bidirectional Mendelian Randomization Study2024 Mononucleosis and IBD risk
Risk of inflammatory bowel disease following hospitalisation with infectious mononucleosis: nationwide cohort study from Denmark -
Post operative recurrence in CD
5ASA postop
5ASA postop II
5ASA vs AZA postop
5ASA vs AZA postop
6mp/5ASA postop
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Perianal disease
Parks classification
PDAI (perianal disease activity index)
TOpClass classification
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FATIGUE & Quality of Life
PROMIS (Patient-Reported Outcomes Measurement Information System)
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United European Gastroenterology
2021 Microscopic Colitis
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GENETICS & OMICS
2023 LHFPL3-AS2 lncRNA in CD
Reduced *LHFPL3-AS2* lncRNA expression is linked to altered epithelial polarity and proliferation, and to ileal ulceration in Crohn disease2023 IBD within and across families
Risk Factors for Developing Inflammatory Bowel Disease Within and Across Families with a Family History of IBD2023 HLA-DRB1*01:03 and Severe Ulcerative Colitis
2023 Genetic architecture of IBD across East Asia & Europe
Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries2023 Epigenetic Analysis of the Trial of Prevention of Post-operative CD
Genome-Wide Methylation Profiling in 229 Patients With Crohn’s Disease Requiring Intestinal Resection: Epigenetic Analysis of the Trial of Prevention of Post-operative Crohn’s Disease (TOPPIC) -
History
1976 AG Parks et al perianal disease PARKS classification
1976 SM Samuelsson describes association between Former smokers and UC
1976 WR Best et al CDAI score in CD
1962 TNF discovery by WE O’Malley et al
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UC proctitis
2020 tacro/beclo
2017 topic tacro
2013 5ASA sup
2000 5ASA sup
1984 4ASA enema
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European Society for Paediatric Gastroenterology Hepatology and Nutrition
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Pregnancy and breastfeeding
2023 Maternal Smoking, Offspring Smoking, Genetic Susceptibility & IBD
Impact of Maternal Smoking, Offspring Smoking, and Genetic Susceptibility on Crohn’s Disease and Ulcerative Colitis2023 Maternal antibiotic exposure
Maternal antibiotic exposure during pregnancy and risk of IBD in offspring: a population-based cohort study2021 Mode of delivery meta-analysis
2020 Passive smoking from the mother & IBD
Association between Passive Smoking from the Mother and Pediatric Crohn’s Disease: A Japanese Multicenter Study2019 Fetal & early life antibiotics & very early IBD
Fetal and early life antibiotics exposure and very early onset inflammatory bowel disease: a population-based study -
Perianal disease
ULTRA SUMMARY
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POUCHITIS
Pouch disease activity index
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World Society of Emergency Surgery & American Association for the Surgery of Trauma
2021 WSES-AAST IBD management in emergency setting
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EXERCISE & OBESITY
2025 severe obesity & IBD risk
Severe obesity, a susceptibility factor for developing inflammatory bowel disease: results of a population-based study2024 physical activity & IBD meta analysis
Physical Activity Is Associated With A Decreased Risk Of Developing Inflammatory Bowel Disease: A Systematic Review And Meta-Analysis2022 Physical activity in childhood
2022 OBESITY-IBD risk meta analysis
A systematic review and meta-analysis of prospective studies on obesity and risk of inflammatory bowel disease2022 OBESITY-CD meta analysis
Obesity is Associated With Increased Risk of CD, but not UC (pooled analysis of 5 cohort studies) -
Canadian Association of Gastroenterology
2016 Consensus on the Management of IBD in Pregnancy
2014 Position statement thiopurines in IBD
2014 Consensus on the Risk, Prevention & Treatment of Venous Thromboembolism in IBD
2013 Position statement on biologics in IBD
2012 Consensus on the treatment of hospitalized ASUC
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Mental health
2023 Prevalance Depression/ Anxiety and IBD- meta-analysis
Prevalence of symptoms of anxiety and depression in patients with inflammatory bowel disease: a systematic review and meta-analysis2023 Depression/ Anxiety and IBD
The bidirectional risk of inflammatory bowel disease and anxiety or depression: A systematic review and meta-analysis2023 Depression/ Anxiety and bipolar disorder in IBD
Longitudinal trajectories of anxiety, depression, and bipolar disorder in inflammatory bowel disease: a population-based cohort study2022 Schizophrenia & IBD risk
Schizophrenia and risk of new-onset inflammatory bowel disease: a nationwide longitudinal study2022 Schizophrenia & IBD mendelian randomization study
Estimation of the bidirectional relationship between schizophrenia and inflammatory bowel disease using the mendelian randomization approach -
URBAN LIVING & POLLUTION
2024 Farming activities & IBD
Farming activities and risk of inflammatory bowel disease: a French nationwide population-based cohort study2024 Air pollution & UC risk
Exposure to air pollution increases susceptibility to ulcerative colitis through epigenetic alterations in CXCR2 and MHC class III region2024 agriculture, biodiversity, green space & IBD
Association between early life exposure to agriculture, biodiversity, and green space and risk of inflammatory bowel disease: a population-based cohort study2023 PFAS exposure & IBD
Per- and poly-fluoroalkyl substances (PFAS) exposure is associated with later occurrence of inflammatory bowel disease2023 Early life hygiene factors
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GEDIIB (THE BRAZILIAN ORGANIZATION OF CROHN'S DISEASE AND COLITIS)
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OTHER DRUGS
2023 PPI & IBD before and after diagnosis
2023 PPI & IBD
Prevalence and Risk Factors Associated With Inflammatory Bowel Disease in Patients Using Proton-Pump Inhibitors: A Population-Based Study2023 Isotretinoin & IBD risk meta-analysis
Systematic review with meta-analysis: environmental and dietary differences of IBD in Eastern and Western populations2023 Antibiotics, Hormonal therapies, contraceptives, NSAIDs & IBD
Associations of Antibiotics, Hormonal Therapies, Oral Contraceptives, and Long-Term NSAIDS With Inflammatory Bowel Disease: Results From the Prospective Urban Rural Epidemiology (PURE) Study2022 PPI & IBD risk meta-analysis
Proton pump inhibitors use and risk of inflammatory bowel diseases: a meta-analysis of observational studies -
BARRIER DYSFUNCTION
2023 Immune response & barrier dysfunction in CD
Immune response and barrier dysfunction-related proteomic signatures in preclinical phase of Crohn’s disease highlight earliest events of pathogenesis2023 Mucin & pediatric IBD
Aberrant Mucin Expression Profiles Associate With Pediatric Inflammatory Bowel Disease Presentation and Activity2020 Intestinal permeability & CD
2019 Intestinal permeability genetic association in CD and healthy first-degree relatives
Analysis of Genetic Association of Intestinal Permeability in Healthy First-degree Relatives of Patients with Crohn’s Disease2015 Determinants of intestinal permeability in CD
Determinants of Intestinal Permeability in Healthy First-Degree Relatives of Individuals with Crohn’s Disease -
GEOGRAPHY
2023 Differential IBD diagnosis based on race/immigration status
Differential Manifestations of Inflammatory Bowel Disease Based on Race and Immigration Status2019 Population density in Asia-Pacific & IBD
Population Density and Risk of Inflammatory Bowel Disease: A Prospective Population-Based Study in 13 Countries or Regions in Asia-Pacific2019 Sex-based differences in Asia-Pacific & IBD
Sex-based differences in the incidence of inflammatory bowel diseases—pooled analysis of population-based studies from the Asia-Pacific region2018 Sex-based differences in Western countries & IBD
Sex-Based Differences in Incidence of Inflammatory Bowel Diseases-Pooled Analysis of Population-Based Studies From Western Countries2015 Vitamin D, UVA, geography and IBD
Association between 25(OH)D Level, Ultraviolet Exposure, Geographical Location, and Inflammatory Bowel Disease Activity: A Systematic Review and Meta-Analysis -
Other expert consensus
2024 Pediatric to Adult Transition in IBD: Australia & New Zealand
2024 fibrostenosing small bowel CD
2022 Therapeutic drug monitoring of biologics in IBD
2022 Australian preconception, pregnancy and breast feeding in IBD
2020 Dietary guidance in IBD- IOIBD consensus
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OTHER FACTORS
1994 Childhood infections & IBD risk
1994 IBD risk and domestic hygiene in infancy
1990 UC risk, smoking & alcohol (Japan)
A Case-Control Study of Ulcerative Colitis with Relation to Smoking Habits and Alcohol Consumption in Japan1990 Perinatal risk factors & IBD kids
1987 Childhood factors & IBD kids
