Timeline
Step into the IBD Timeline and embark on a journey through the chronological milestones, breakthroughs, and significant studies that have shaped the understanding and treatment of IBD. Explore the evolution of research, therapies, and key discoveries that have paved the way for advancements in IBD care.
Coming soon…
List with the upcoming studies
ACCURE
ACCURE-UK
COSTA
SEQUENCE
PROFILE
STATIC
IASO
REPREVIO
SOPRANO-CD
MEERKAT
SPICY
TITRATE
TRIBUTE
COMBINE
COMMET
TENOR
QUASAR
UNIFI Jr
DUMBO
PREdiCCt
IVEMEI
JUNIPER
SERENITY
NOR-DRUM B
COTTONWOOD
INTREPID
ELDERLUST
RESERVO
VERSUS CD
LOVE-UC
EXPLORER
EXPEDITION
AMBER 2
BIOSCOPE
PREVEDO
PROFUST
VERDICT
CD HOPE
DIETOMICS CD
GRAVITI
CONCLUDE
DUET UC
POWER
SEMI-VEG
PIONIR
MELODY
VALUE
OATS
CD-TDI
PROACTIVE
ADDapt
LIBERTY-UC
LIBERTY-CD
CD-TREAT
IBD-FITT
ACHILLES
LATTICE-UC
USTAP
DIVERSITY
YELLOWSTONE
and many more
2024
COCONUT WATER-UC
Coconut water vs placebo in active mild-moderate UC patients on standard medication
PROFILE
A biomarker-stratified comparison of top-down versus accelerated step-up treatment strategies for patients with newly diagnosed Crohn’s disease (PROFILE): a multicentre, open-label randomised controlled trial
ASTIClite
Safety and efficacy of autologous haematopoietic stem-cell transplantation with low-dose cyclophosphamide mobilisation and reduced intensity conditioning versus standard of care in refractory Crohn’s disease (ASTIClite): an open-label, multicentre, randomised controlled trial
Reverse-engineered EEN
Reverse-engineered exclusive enteral nutrition in pediatric Crohn’s disease: A pilot trial
See summary
PROTECT 1/2
Modified-Release Phosphatidylcholine (LT-02) for Ulcerative Colitis: Two Double-Blind, Randomized, Placebo-Controlled Trials
2024 ENTERPRET
A Randomized Controlled Trial of Vedolizumab Dose Optimization in Patients With Ulcerative Colitis Who Have Early Nonresponse
2024
2023
TACOS
GALAXI-1
Phase 2 trial, guselkumab in Crohn’s disease efficacy and safety at week 48
The decider study
Allopurinol-thiopurine versus standard thiopurine in patients with IBD
OTC multivitamin/mineral supplement
Over-the-Counter Multivitamin and Mineral Supplement to Prevent Infections in IBD Patients
5ASA MMX kids
EXPLORER
U-ACHIEVE maintenance
VIBRATO
Vagus nerve stimulation
ORCHID
MCP-UC
POPEYE
Ferric carboxymaltose vs Ferrous fumarate in Anemic children with IBD
COMBINE
LUCENT 1 & 2
Curcumin-QingDai
U-EXCEL;U-EXCEED; U-ENDURE
Mediterranean diet
LAG-3 depleting Ab
Olamkicept
DIVERGENCE 1
EARNEST
ELEVATE
RUN-CD
VEDOKIDS
SPARE
VEGA
BERGAMOT
LADI
SLRIPS
BETA-FRUCTANS
Ritlecitinib-brepocitinib
5ASA CD
2022
Protdilat
Self-expandable metal stents vs endoscopic balloon dilation for the treatment of strictures in Crohn’s disease
U-ACHIEVE & U-ACCOMPLISH
AID vs CFG -UC
Anti-Inflammatory Diet Prevents Subclinical Colonic Inflammation and Alters Metabolomic Profile of UC in Clinical Remission
See summary
5HTP-fatigue
CDED-AD
The Crohn’s disease exclusion diet for induction and maintenance of remission in CD
See summary
LOTUS
ABX464-OBEFAZIMOD
FMT-AID
Faecal microbiota transplantation with anti-inflammatory diet (FMT-AID) in UC induction and maintenance
PIANO registry
AAUC
LAUREL
HICKORY
HIBISCUS I&II
STARDUST
TISkids
SUSTAIN
GALAXI 1
SEAVUE
SERENE-UC
SERENE-CD
REMSWITCH
COMBO-MESA
CRAFT-UC
STOP-IT
VISIBLE 2
ERIca
ENTERPRISE
ADVANCE & MOTIVATE
FORTIFY
TOUR
VIP
AJM300
HUBBLE
PUCCINI
PISA-II
Mirikizumab-ph2-CD
Surgery and antiTNF perianal CD
Surgical closure, mainly with glue injection and anti-tumour necrosis factor α, in perianal CD
See summary
Spesolimab
2022
2021
SELECTION
Low fat high fibre diet UC
Low-Fat, High-Fiber Diet Reduces Markers of Inflammation and Dysbiosis and Improves Quality of Life in UC
EEN in UC
TRUE NORTH
DINE-CD
GARDENIA
CLARITY
UNISTAR
TOUCHSTONE-OLE
OASIS-OLE
ENVISION I
STRIDENT
FUTURE
RIVETING
VOLTAIRE-CD
IFX IV/SC
PRECISION
NOR-DRUM A
NOR-DRUM B
2020
VISIBLE 1
CELEST
U-ACHIEVE
CONCEIVE
PISA-I
STEPSTONE
CONDUCT
OASIS
PIANO
I6T-MC-AMAC
PRASCO
PRESENCE
SUPREME-CD
AZA to avoid A-D-Ab
2º antiTNF +/- Azathioprine in IBD patients who had immune mediated LOR to first antiTNF
TACRO/BECLO
Tacrolimus suppositories vs beclomethasone suppositories in proctitis
SCD diet ped-CD
Specific Carbohydrate Diet and Diet Modification as Induction Therapy for Pediatric CD
Mirikizumab-phase2 UC
Low FODMAP-IBD
Low FODMAP trial on Symptoms, Fecal Microbiome, and Markers of Inflammation in Patients With Quiescent Inflammatory Bowel Disease
2020
2019
UNIFI
PANTS
VARSITY
VERSIFY
LOVE-CD
CDED+PEN
Crohn’s Disease Exclusion Diet Plus Partial Enteral Nutrition Induces Sustained Remission in a Randomized Controlled Trial
See summary
FACES
PAILOT
DIAMOND 2
PLANET CD
Abrilumab
ADA-pouchitis
2018
INDIGO NATURALIS
IFX postop
TEDDY
MERIT-UC
OPERA
TAILORIX
ATICCA
SECURE
BUDEFOAM
ADMIRE-CD
Budesonide-CD
2018
2017
MUPPIT
Once- Versus Twice-daily Mesalazine to Induce Remission in Paediatric Ulcerative Colitis: A Randomised Controlled Trial
Risankizumab ph2-cd
no-carrageenan diet UC
Multidonor FMT
CREOLE
CALM
Adalimumab +/- azathioprine tight control vs clincal management in CD
ENCORE-CD
NOR-SWITCH
CT-P13 or infliximab originator in immune mediated inflammatory diseases
OCTAVE 1&2
EXTEND
LIR!C
FITZROY
TURANDOT
GOLI kids
APPRECIA
TOPIC TACRO
EEN in CD
Budesonide- CD Japan
Efficacy and Safety of Oral Budesonide in Patients with Active
Crohn’s Disease in Japan: A Multicenter, Double-Blind,
Randomized, Parallel-Group Phase 3 Study
2016
UNITI I&II
IM-UNITI
Ustekinumab in CD safety
DIAMOND
COLLECT
ADMIRE-CD
Allogeneic adipose-derived mesenchymal stem cells (Cx601) in perianal CD
TOUCHSTONE
CONSTRUCT
METEOR
ART
TOPPIC
PREVENT
Australian vs low FODMAP diet
Consistent Prebiotic Effect on Gut Microbiota With Altered FODMAP Intake in Patients with CD
IGG4-exclusion diet
2016
2015
STRIDE
REACT
TAXIT
PURSUIT-IV
POCER
MTX kids SC/PO
Thalidomide kids UC
VSL3 postop
BUDEFOAM
BETA
Beclomethasone Dipropionate and Prednisone in the Treatment of Active UC
MSC perianal disease
Allogeneic Bone Marrow–Derived Mesenchymal Stromal Cells in Perianal Fistulas in CD
See summary
Mongersen -CD
Mongersen, an Oral SMAD7 Antisense Oligonucleotide, and Crohn’s Disease
Vercirnon-CD
Randomised clinical trial: vercirnon, an oral CCR9 antagonist,vs. placebo as induction therapy in active Crohn’s disease
2014
GEMINI III
UC-SUCCESS
PURSUIT-SC
PURSUIT-M
ADAFI
ADA in UC Japan
FHAST-1
AST-120 (Spherical Carbon Adsorbent) in the Treatment of Perianal Fistulae in Mild-to-Moderate CD
See summary
COMMIT
IFX/ADA postop
5ASA dose kids
GROWTH-CD
2014
2013
MOTUS
MUSIC
IFX kids
GEMINI I
GEMINI II
Thalidomide kids CD
AZA/ IFX postop
RAPID
AZTEC
Cipro postop
AZA +/- METRO postop
5ASA sup
Cow Milk Protein exclusion diet ped-UC
Budesonide-CD
Apheresis-CD
A randomised, double-blind, sham-controlled study of granulocyte/monocyte apheresis for moderate to severe Crohn’s disease
See summary
ULTRA II
STORI
EXTEND
ADA in Japanese-CD
PODIUM
SWITCH
IMAgINE 1
CERTIFI
CYSIF
CORE I
IFX postop
ADA/AZA/5ASA postop
TACRO UC
SECUKINUMAB
APHERESIS-CD
A randomised, double-blind, sham-controlled study of granulocyte/monocyte apheresis for moderate to severe Crohn’s disease
2012
2011
ULTRA I
WELCOME
5ASA vs budesonide-UC
5ASA vs budesonide-CD
FOS-CD
2010
SONIC
PRECiSE III
PRECiSE 4
ADHERE
5ASA vs AZA postop
Metronidazole ointment perianal CD
Fibrin glue perianal CD
IgG Food antigen CD
2010
2009
IFX postop
AZA/5ASA postop
5ASA-MMX Asacol
2008
SUTD
METRO+/- AZA postop
Balsalazide
Everolimus vs AZA
AST-120 perianal CD
Oral Spherical Adsorptive Carbon for the Treatment of Intractable Anal Fistulas in CD
Clarithromycin in CD
randomized study of clarithromycin versus placebo in active Crohn’s disease
EPIC 1 & 2
Omega-3 Free Fatty Acids for the Maintenance of Remission in Crohn Disease
2008
2007
CLASSIC II
CHARM
REACH
ASCEND I
Mesalazine high/low dose in UC
PRECiSE I
PRECiSE II
GAIN
Natalizumab+IFX
Safety and Tolerability of Concurrent Natalizumab Treatment for Patients with Crohn’s Disease Not in Remission While Receiving Infliximab
synbiotics postop
Probiotics postop
DIET in CD
topical tacrolimus in PCD
Antibiotic combo in CD
Two-Year Combination Antibiotic Therapy With Clarithromycin, Rifabutin, and Clofazimine for Crohn’s Disease
2006
TREAT
CLASSIC I
TACRO UC
probiotics postop
5ASA-AZA
PEN vs TEN diet CD
Half elemental diet CD
Effectiveness of an ‘half elemental diet’ as maintenance therapy for CD
See summary
Polymeric diet vs steroids
Polymeric Diet Alone Versus Corticosteroids in the Treatment of Active Pediatric Crohn’s Disease: A Randomized Controlle Open-Label Trial
2006
2005
PINCE
ACT 1&2
LGG kids
Ornidazol postop
ENACT-1 & 2
Budesonide longterm-CD
Microparticle diet CD
Lack of efficacy of a reduced microparticle diet in a multi-centred trial of patients with active CD
2004
BUDE/PRED kids
ACCENT II
IFX +/- ciprofloxacin perianal cd
5ASA/AZA postop
5ASA/6MP postop
Aloe vera in UC
2004
2003
CYCLO 2/4
5ASA postop
Oral tacrolimus fistulizing CD
Steroids & Immunogenicity
EGF enema
Natalizumab
2002
ACCENT I
Lactobacillus postop
Beclomethasone
Budesonide-CD
2002
2001
CICLO vs STEROIDS
5ASA foam enema
2000
MCP kids
MCP-MTX-5ASA
MTX-CD
5ASA postop
5ASA sup
2000
1999
Plantago ovata
IFX-CD
IFX-fistulising CD
1998
Budesonide vs mesalazine-cd
1998
1997
IFX-CD
1996
Methotrexate- UC
Omega3 & Low carbohydrate diet CD
Omega-3 Fatty Acids and Low Carbohydrate Diet for Maintenance of Remission in CD
See summary
1996
1995
IFX-cA2
METRO postop
MTX- CD
AZA-CD
Elimination diet-UC
Elimination diet in the management of patients with ulcerative colitis
See summary
1994
Budesonide -CD
Hyperbaric oxygen-perianal CD
Hyperbaric oxygen in perianal CD
Oral 5ASA -CD
Oral 5ASA in ileocolonic and colonic CD
1994
1993
Mesalamine CD
Mesalamine for CD a 16-week trial
Prednisone +/- Azathioprine- CD
1992
1992
1991
fecal stream postop
Metronidazole-CD
Double blind, placebo controlled trial of metronidazole
in Crohn’s disease
1990
Smoking & postop recurrence
Slow release 5ASA in CD
Slow-Release 5-Amino-Salicylic Acid (Pentasa®) for the Treatment of Active Crohn’s Disease
1990
1987
5ASA-CD
Incision +/- fistulotomy pCD
1986
1986
1985
fecal stream postop
Diet trial CD
Unrefined carbohydrate fibre rich diet vs diet with exclusion of specific foods in the maintenance of remission in CD
See summary
Low residue diet CD
EEN in CD
Controlled trial comparing prednisolone with an elemental diet plus non-absorbable antibiotics in active Crohn’s disease
1984
4ASA enemas
sulfasalazine & 6-methylprednisolone in CD
European Cooperative Crohn’s Disease Study (ECCDS): results of drug treatment
See summary
1984
1983
Supplemented oral nutrition CD
1982
TRANEXAMIC
1982
1981
5ASA enema
1980
Sulphapyridine vs 5-ASA
Mercaptopurine-CD
1980
1979
Pred- AZA-Sulphapyridine in CD
1978
Prednisone single/multiple doses UC
Steroids-CD
1978
1977
Metronidazol UC
1974
Azathioprine UC
Azathioprine CD
Salazopyrin CD
1974
1973
Sulphasalazine UC
1972
1972
1971
Azathioprine-CD
Azathioprine-CD II
1968
1968
1967
1966
1966
1965
Prednisone maintenance UC
Sulphasalazine maintenance UC
Various diets UC
A Controlled Therapeutic Trial of Various Diets in Ulcerative Colitis
See summary
1964
1964
1963
1962
Prednisone in UC
Steroids vs sulphasalazine in UC
Sulphasalazine in UC
Steroid sup UC proctitis
1962
1961
1960
corticosteroids in uc
oral steroids vs topical vs Salazopyrin
Prednisone, Salazopyrin and Topical Hydrocortisone Hemisuccinate in UC
1960
1959
Cortisone and corticotrophin in uc
1958
Topical Hydrocortisone
Topical Hydrocortisone Hemisuccinate Sodium for induction of remission UC
Topical Hydrocortisone II
Topical Hydrocortisone Hemisuccinate Sodium for induction of remission UC
1958
1955
cortisone in asuc
Any suggestions?
If you have any suggestion of trials or studies to add, changes or corrections of any error, feel free to write me here
Illustrations by Cristina Gros Content creator and development Beatriz Gros
