IBD History
Tracing the Origins of Inflammatory Bowel Disease: From the first documented cases to the identification of key genetic markers, the history of IBD is marked by significant milestones. Discover the earliest descriptions of Crohn’s disease and ulcerative colitis, the breakthroughs in genetic research, and the evolution of initial treatments that paved the way for modern advancements.

CROHN’S DISEASE

H Park et ak Th17 discovery, a unique T helper lineage that regulates tissue inflammation
M Silverberg et al publish the Montreal classifications
2005
2001
JP HUGOT association between NOD2 variants and CD risk
CROHN’S DISEASE

K GEBOES et al histological assessment of inflammation in ulcerative colitis
2000
1998
Gavriel Iddan invents the capsule endoscopy
CROHN’S DISEASE

First trial using infliximab in CD
1997
1996
JP Hugot Mapping of a susceptibility locus for CD on chromosome 16
CROHN’S DISEASE

LR Sutherland et al. Effect of smoking on postoperative recurrence in CD
P Rutgeerts et al publish the Rutgeerts postoperative recurrence score
1990
1987
KW Schroeder et al published the Full Mayo Score
CROHN’S DISEASE

Tracey KJ et al Monoclonal antibody against TNF for septic shock due to bacteraemia
1986
1985
PH Harper et al. Role of the faecal stream in the maintenance of Crohn's colitis
CROHN’S DISEASE

1984
1983
Dale I et al first description of calprotectin (initially named L1 Antigen)
CROHN’S DISEASE

J Rhodes describes the association between Smoking & CD
1982
1980
RF Harvey & JM Bradshaw publish the Harvey-Bradshaw index
CROHN’S DISEASE

SM Samuelsson describes association between Former smokers and UC
AG Parks et al perianal disease PARKS classification
WR Best et al CDAI score in CD
1976
1969
William Wolff & Hiromi Shinya invented the fiberoptic colonoscope
CROHN’S DISEASE

TNF discovery by WE O'Malley et al
1962
1957
Basil Hirschowitz & Larry Curtiss invent the Flexible fiberoptic endoscope prototype
CROHN’S DISEASE

AG Melrose “The geographical incidence of chronic ulcerative colitis in Britain” First report of UC incidence
Felsen J & W Wolarsky Familial ulcerative colitis and ileltis- CD incidence
First trial in UC using cortisone
1955
1948
Nanna Svartz First publication using sulphasalazine in UC
CROHN’S DISEASE

1940
1938
A Penner and BB Crohn describe perianal disease associated with regional ileitis
CROHN’S DISEASE

Burrill Crohn, Leon Ginzburg & Gordon Oppenheimer "Regional ileitis
1932
1930
WS Tillet & T Francis identify what we know as C-reactive protein
CROHN’S DISEASE

1920
1913
T. Kennedy Dalziel Chronic interstitial enteritis
CROHN’S DISEASE

”Symposium
1909
1875
Samuel Wilks & Walter Moxon Book introducing UC
CROHN’S DISEASE

Gustave Trouvé- first electrically illuminated endoscope
1873
1859
Samuel Wilks “Morbid Appearances in the Intestines of Miss Bankes”- UC case
CROHN’S DISEASE

*Historical descriptions of bowel diseases that may have been IBD date back to reports from the Chinese and Roman empires
Preceding history
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Illustrations by Cristina Gros Content creator and development Beatriz Gros
Illustrations by Cristina Gros Content creator and development Beatriz Gros