IBD History

Tracing the Origins of Inflammatory Bowel Disease: From the first documented cases to the identification of key genetic markers, the history of IBD is marked by significant milestones. Discover the earliest descriptions of Crohn’s disease and ulcerative colitis, the breakthroughs in genetic research, and the evolution of initial treatments that paved the way for modern advancements.

CROHN’S DISEASE

H Park et ak Th17 discovery, a unique T helper lineage that regulates tissue inflammation
M Silverberg et al publish the Montreal classifications

2005

2001

JP HUGOT association between NOD2 variants and CD risk

CROHN’S DISEASE

K GEBOES et al histological assessment of inflammation in ulcerative colitis

2000

1998

Gavriel Iddan invents the capsule endoscopy

CROHN’S DISEASE

First trial using infliximab in CD

1997

1996

JP Hugot Mapping of a susceptibility locus for CD on chromosome 16

CROHN’S DISEASE

LR Sutherland et al. Effect of smoking on postoperative recurrence in CD
P Rutgeerts et al publish the Rutgeerts postoperative recurrence score

1990

1987

KW Schroeder et al published the Full Mayo Score

CROHN’S DISEASE

Tracey KJ et al Monoclonal antibody against TNF for septic shock due to bacteraemia

1986

1985

PH Harper et al. Role of the faecal stream in the maintenance of Crohn's colitis

CROHN’S DISEASE

1984

1983

Dale I et al first description of calprotectin (initially named L1 Antigen)

CROHN’S DISEASE

J Rhodes describes the association between Smoking & CD

1982

1980

RF Harvey & JM Bradshaw publish the Harvey-Bradshaw index

CROHN’S DISEASE

SM Samuelsson describes association between Former smokers and UC
AG Parks et al perianal disease PARKS classification
WR Best et al CDAI score in CD

1976

1969

William Wolff & Hiromi Shinya invented the fiberoptic colonoscope

CROHN’S DISEASE

TNF discovery by WE O'Malley et al

1962

1957

Basil Hirschowitz & Larry Curtiss invent the Flexible fiberoptic endoscope prototype

CROHN’S DISEASE

AG Melrose “The geographical incidence of chronic ulcerative colitis in Britain” First report of UC incidence
Felsen J & W Wolarsky Familial ulcerative colitis and ileltis- CD incidence
First trial in UC using cortisone

1955

1948

Nanna Svartz First publication using sulphasalazine in UC

CROHN’S DISEASE

1940

1938

A Penner and BB Crohn describe perianal disease associated with regional ileitis

CROHN’S DISEASE

Burrill Crohn, Leon Ginzburg & Gordon Oppenheimer "Regional ileitis

1932

1930

WS Tillet & T Francis identify what we know as C-reactive protein

CROHN’S DISEASE

1920

1913

T. Kennedy Dalziel Chronic interstitial enteritis

CROHN’S DISEASE

”Symposium

1909

1875

Samuel Wilks & Walter Moxon Book introducing UC

CROHN’S DISEASE

Gustave Trouvé- first electrically illuminated endoscope

1873

1859

Samuel Wilks “Morbid Appearances in the Intestines of Miss Bankes”- UC case

CROHN’S DISEASE

*Historical descriptions of bowel diseases that may have been IBD date back to reports from the Chinese and Roman empires

Preceding history

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