2023 LHFPL3-AS2 lncRNA in CD

Reduced *LHFPL3-AS2* lncRNA expression is linked to altered epithelial polarity and proliferation, and to ileal ulceration in Crohn disease

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*Historical descriptions of bowel diseases that may have been IBD date back to reports from the Chinese and Roman empires

1859 Samuel Wilks “Morbid Appearances in the Intestines of Miss Bankes”- UC case

1873 Gustave Trouvé- first electrically illuminated endoscope

1875 Samuel Wilks & Walter Moxon Book introducing UC

1909 “Symposium”

1913 T. Kennedy Dalziel Chronic interstitial enteritis